KMID : 1001020130110010033
|
|
Korean Journal of Urological Oncology 2013 Volume.11 No. 1 p.33 ~ p.40
|
|
Histopathological Evaluation of Non-Neoplastic Renal Parenchyma Adjacent to Tumors in Partial Nephrectomy Specimens of Renal Cell Carcinoma
|
|
Lee Sang-Hyup
Kim Tae-Hyoung Myung Soon-Chul Moon Young-Tae Kim Kyung-Do Kim Jung-Hoon
|
|
Abstract
|
|
|
Purpose: The optimal margin for partial nephrectomy of renal cell carcinoma (RCC) has not been clearly defined. We investigated the viability of glomeruli and tubules in non-neoplastic renal parenchyma adjacent to tumors and analyzed the predictive factors that affect them. Materials and Methods: Data were gathered retrospectively from 64 patients who underwent partial nephrectomy for RCC between January 2008 and December 2011. We evaluated glomerular viability of non-neoplastic renal parenchyma adjacent to tumors using H&E staining and tubular viability was assessed by Klotho stain. Each renal unit was assigned a RENAL nephrometry score using preoperative imaging. We also investigated the correlation between RENAL score, estimated glomerular filtration rate (GFR) and glomerular and tubular viability. Results: The percentage of non-viable glomeruli was higher in the region within 2-mm from the tumor compared with the region£¾2-mm from the tumor. The mean non-viable tubular distance from the tumor was 1.36¡¾0.597mm. Only the correlation between glomerular non-viability (%) within 2-mm from the tumor and non-viable tubular distance (mm) was significant. Correlations between RENAL score and glomerular non-viability in the region ¡Â2- mm from the tumor and non-viable tubular distance were not significant for all RENAL factors. But, glomerular non-viability 5-10-mm from the tumor was inversely correlated with preoperative estimated GFR. Conclusions: Regardless of RENAL nephrometry scores, the viability of glomeruli and tubules within 2-mm from RCC was affected by tumor mass, and that £¾5-mm from the tumor was affected by subclinical comorbidities. These may suggest new guidelines of RCC management intraoperatively and postoperatively
|
|
KEYWORD
|
|
Renal cell carcinoma, Renal parenchyma, Nephrectomy
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|